LEARNING OUTCOMES
Aims and Scope
It is the basic introductory course to the study of Pharmacology.
This course aims at providing students with knowledge concerning the General principles of pharmacology, data on Pharmacodynamics – Pharmacokinetics, prescriptions and study of special pharmacology. The objective of the course is to familiarize students with data on the effect of certain types of drugs, such as Analgesics – Anti-inflammatory, antidiabetic, Sera – Vaccines, immunoglobulins, chemotherapeutics, antineoplastic etc.
Upon successful completion of the course the students will be able to understand:
- The mechanism of action of drugs
- Their interactions with the biological substrate
- The applications in the prevention, diagnosis and treatment of the disease
SYLLABUS
1. Basic principles of Pharmacokinetics (absorption from the skin and mucous membranes, distribution, metabolism, excretion), Pharmacodynamics-Mechanisms of action, Adverse effects, Overdose-Toxicity.
2. Forms and routes of administration, Pharmacokinetic-Pharmacodynamic data, Conjugation, Therapeutic index, Toxicity.
3. Release, absorption, bioavailability, bioequivalence, distribution, protein binding, Pharmacokinetic models, Skin absorption, Lipophilia, Transdermal absorption studies.
4. Drug Metabolism, Cytochrome P450. Genetic factors affecting metabolism. Pharmacogenetics/Pharmacogenomics. Drug excretion, half-life.
5. Gastrointestinal drugs (antacids, proton pump inhibitors, histamine receptor blockers).
6. Medicines for angina, myocardial infarction and coronary syndromes, heart failure, Antihypertensives, Lipid-Lowering Agents, Antiplatelets, Anticoagulants, Antiasthmatics).
7. Drugs of the Nervous System (Antiepileptics, Migraines, Multiple Sclerosis, Parkinson’s disease, Antipsychotics, Antidepressants, Anxiolytics, Hypnotics.
8. Antimicrobials – route of administration (antibacterial, antitubercular, antifungal, antiviral).
9. Medicines for endocrine diseases (pancreatic, thyroid, obesity, bone metabolism, pituitary and adrenal cortex).
10. Anti-inflammatory (steroidal and non-steroidal).
11. Hormonal contraceptive drugs, Hormone replacement, Anti-estrogens, Anti-androgens
12. Anticancer drugs, Adverse effects of anticancer drugs, Chemotherapy, Immunotherapy
13. Narcotic analgesics