DELIVERY SYSTEMS OF ACTIVE SUBSTANCES

LEARNING OUTCOMES

The aim of the course is for students to understand the applications of the delivery systems used for increase of bio-availability of the active ingredients used in topical dermal preparations.

The goal of the course is for students to acquire the knowledge of the molecular design and development of advanced delivery systems of bioactive substances used in skin preparations.

Learning outcomes
After the end of the course students will be able to:

• design and develop delivery systems for the increase of dermal permeability of bioactive substances
• investigate a) mechanisms of release of the substances of these systems b) the physicochemical stability of the systems and the stability of bioactive substances in these systems
• Know the basic principles of nanotechnology of the skin care products
• Compare the advantages and disadvantages of the delivery systems used fir the increase of bioavailability of active ingredients
• Evaluate the environmental impact of the nanotechnology used in skin care products

SYLLABUS

1. Delivery systems of bioactive substances. Nanotechnology. Nanometrology. Physicochemical properties of nan-delivery systems, techniques fir the characterization0electron microscopy, size dispersity index, aggregation. Nanocolloids. Applications in biomedical sciences.
2. Deliver complexes. Colloids and non colloids
3. Nan=emulsions. Liposomes-methods of preparations-methods of stability testing. Release of the incorporated ingredient. Advantages-Disadvantages of liposomes in skin care products
4. Liquid crystals. Dendrimers. Liquid crystals as emulsifiers.
5. Fullerenes. Application of fullerenes in Cosmetic Science.
6. Solid lipid nanoparticles (SLN)
7. Polymeric nanoparticles, Nanocapsules and lipid nanocarriers (NLC). Biodegradable polymers. Encapsulation of essential oils. Mechanism of release of the encapsulated ingredients
8. Metal nanoparticles and nanoparticles of chemical compounds of metals. Nano-sunscrrens-photoprotection
9. Gels. Nanofibrils, nanochitin
10. Cosmetic-textiles for the release of active substances
11. Nanotechnology in Dermatology
12. Disadvantages of the application of nano-systems
13. Introduction to regulatory affairs regarding the nanotechnology and the research in this field. Impact of nan-materials on aqueous environment.